Sharing Knowledge is Building Science
Selected publications and patents
by Sandra A.C.Figueiredo, Jorge A.R.Salvador, Roldán Cortés, Marta Cascante
European Journal of Medicinal Chemistry,Vol139, 20 Oct 2017, Pag 836-848. DOI: 10.1016/j.ejmech.2017.08.058
Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment.
by Judite R. M. Coimbra, Daniela F. F. Marques, Salete J. Baptista, Cláudia M. F. Pereira, PaulaI. Moreira, Teresa C. P. Dinis, Armanda E. Santos, and Jorge A. R. Salvador
Frontiers in Chemistry, 24 May 2018, DOI: 10.3389/fchem.2018.00178
Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmacophore Approach
by Salete J. Baptista, Maria M. C. Silva, Elisabetta Moroni, Massimiliano Meli, Giorgio Colombo, Teresa C. P. Dinis and Jorge A. R. Salvador
PLoS ONE 12(1): e0170846, 2017. DOI: 10.1371/journal.pone.0170846
Synthesis and biological evaluation of novel asiatic acid derivatives with anticancer activity
by Gonçalves B. M. F., Salvador J. A. R., Marín S., Cascante M.
RSC Adv., 2016,6, 3967-3985 . DOI: 10.1039/C5RA19120C
by Bruno M. F. Gonçalves, Jorge A. R. Salvador, Diana S. M. Santos, Silvia Marín and Marta Cascante
RSC Adv., 2016,6, 39296-39309 . DOI: 10.1039/C6RA04597A
by Mendes V. I. S., Bartholomeusz G. A., Ayres M., Gandhi V., Salvador J. A. R.
European Journal of Medicinal Chemistry,123, (2016) 317-331. DOI: 10.1016/j.ejmech.2016.07.045
Synthesis and anticancer activity of novel fluorinated asiatic acid derivatives.
by Gonçalves B. M. F., Salvador J. A. R., Marín S., Cascante M.
European Journal of Medicinal Chemistry,114, (2016), Pages 101–117. DOI: 10.1016/j.ejmech.2016.02.057
Pharmaceutical green chemistry applied to the chemical synthesis of steroid compounds.
by Salvador J. A. R.; Pinto R. M. A.; Silvestre S.M.
Current Green Chemistry, 2015, DOI: 10.2174/2213346101666140915212312.
by Sousa M. C., Varandas R., Santos R. C., Santos-Rosa M., Alves V., Salvador J. A. R.
Plos One, 2014, 9, e89939 . DOI: 10.1371/journal.pone.0089939.
VT-NMR and cytotoxic evaluation of some new ortho-(alkylchalcogen)acetanilides.
by Ramos S. S., Almeida S. S., Leira P. M., Boto R. E. F., Silvestre S., Almeida P.
Tetrahedron, 2014, 70, 46, 8930-8937. DOI: 10.1016/j.tet.2014.09.055.
Antitumor effects of celastrol and semi-synthetic derivatives.
by Salvador J. A. R., Santos R. C., Figueiredo S. A. C., Jing Y.
Mini Review in Organic Chemistry, 2014, 11, 400-407. DOI: 10.2174/1570193X1103140915113701.
by Ferreira A., Rodrigues M., Silvestre S., Falcão A., Alves G.
Toxicology in Vitro, 2014, 28, 8, 1531–1535. doi: 10.1016/j.tiv.2014.08.004
Anticancer steroids: linking natural and semi-synthetic compounds.
by Salvador J. A. R., Carvalho J. F. S., Leitão A. J., Neves M. A. C., Silva M. M. C., Silvestre S. M., Sá e Melo, M. L.
Natural Product Reports, 2013, 30, 324-374. doi: 10.1039/C2NP20082A
by Leal A. S. M., Wang R., Salvador J. A. R., Jing Y.
Organic & Biomolecular Chemistry, 2013, 11, 1726-1738. doi: 10.1039/C3OB00011G
Novel Oleanolic vinyl boronates: synthesis and antitumor activity.
by Moreira V. M., Salvador J. A. R., Simões S., Destro F., Gavioli R.
European Journal of Medicinal Chemistry, 2013, 63, 46-56. doi: 10.1016/j.ejmech.2013.01.040.
by Salvador J. A. R., Pinto R. M. A., Silvestre S. M.
The Journal of Steroid Biochemistry and Molecular Biology, 2013, 137, 199-222. doi: 10.1016/j.jsbmb.2013.04.006.
Recent developments in oxidative processes in steroid chemistry.
by Salvador J. A. R., Silvestre S. M., Pinto R. M. A., Le Roux C.
Current Organic Chemistry, 2012, 16, 1243-1276. doi: 10.2174/138527212800564204.
by Salvador J. A. R., Moreira V. M., Pinto R. M. A., Leal A. S., Paixão J. A.
Beilstein Journal of Organic Chemistry, 2012, 8, 164-169. doi: 10.3762/bjoc.8.17.
Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs.
by Salvador J. A. R., Moreira V. M., Gonçalves B. M. F., Leal A. S. M., Jing Y.
Natural Product Reports, 2012, 29, 1463-1479. doi: 10.1039/C2NP20060K.
Bismuth compounds in medicinal chemistry.
by Salvador J. A. R., Figueiredo S. A. C., Pinto R. M. A., Silvestre S. M.
Future Medicinal Chemistry, 2012, 4, (11), 1495-1523. doi: 10.4155/fmc.12.95.
by Leal A. S. M., Salvador J. A. R., Jing Y.
ChemMedChem, 2012, 7, 1635-1646. doi: 10.1002/cmdc.201200282.
by Leal A. S. M., Salvador J. A. R., Jing Y.
Bioorganic & Medicinal Chemistry, 2012, 5774-5786. doi: 10.1016/j.bmc.2012.08.010.
by Carvalho J. F. S., Silva M. M. C., Moreira J. N., Simões S., Sá e Melo M. L.
Journal of Medicinal Chemistry, 2011, 54, 6375-6393. doi: 10.1021/jm200803d.
Bismuth(III) reagents in steroid and terpene chemistry.
by Salvador J. A. R., Silvestre S. M., Pinto R. M. A.
Molecules, 2011, 16, 2884-2913. doi: 10.3390/molecules16042884.
Targeting of mitochondria-endoplasmatic reticulum by fluorescent macrocyclic compounds.
by Cruz C., Cairrão E., Silvestre S., Breitenfeld L., Almeida P., Queiroz J. A.
Plos One, 2011, 6, 11, e27078. doi: 10.1371/journal.pone.0027078.
by Moreira V. M., Salvador J. A. R., Matos Beja A. Paixão J. A.
Steroids, 2011, 76, 582-587. doi: 10.1016/j.steroids.2011.02.009.
by Santos R. C., Salvador J. A. R., Cortés R., Pachón G., Marín S., Cascante M.
Biochimie, 2011, 93, 1065-1075. doi: 10.1016/j.biochi.2011.02.014.
by Salvador J. A. R., Moreira V. M., Pinto R. M. A., Leal A. S., Le Rouc C.
Advanced Synthesis & Catalysis, 2011, 353, 2637-2642. doi: 10.1002/adsc.201100155.
Biocatalytic transformations of steroids: focus on hydrolase-catalyzed reactions.
by Silva, M. M. C., Carvalho J. F. S., Riva S., Sá e Melo M. L.
Current Organic Chemistry, 2011, 15, 6, 928-941. doi: 10.2174/138527211794518871.
by Carvalho. J. F. S., Silva M. M. C., Moreira J. N., Simões S., Sá e Melo M. L.
Journal of Medicinal Chemistry, 2010, 53 (21), 7632-7638. doi: 10.1021/jm1007769.
by Santos R. C., Salvador J. A. R., Marín S., Cascante M., Moreira J. N., Dinis T. P. C.
Bioorganic & Medicinal Chemistry, 2010, 18, 4385-4396. doi: 10.1016/j.bmc.2010.04.085.
Efficient chemoenzymatic synthesis, cytotoxic evaluation, and SAR of epoxysterols.
by Carvalho J. F. S., Silva M. M. C., Moreira J. N., Simões S., Sá e Melo, M. L.
Journal of Medicinal Chemistry, 2009, 52 (13), 4007-4019. doi: 10.1021/jm9003973.
by Salvador J. A. R., Pinto R. M. A., Santos R. C., Le Roux C., Matos Beja A., Paixão J. A.
Organic & Biomolecular Chemistry, 2009, 7, 508-517. doi: 10.1039/B814448F.
by Pinto R. M. A., Salvador J. A. R., Le Roux C., Carvalho R. A., Matos Beja A., Paixão J. A.
Tetrahedron, 2009, 65, 6169-6178. doi: 10.1016/j.tet.2009.05.043.
Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity.
by Santos R. C., Salvador J. A. R., Marín S., Cascante M.
Bioorganic & Medicinal Chemistry, 2009, 17, 6241-6250. doi: 10.1016/j.bmc.2009.07.050.
by Salvador J. A. R., Pinto, R. M. A., Silvestre S. M.
Current Organic Synthesis, 2009, 6, 426-470. doi: 10.2174/157017909789108701.
by Pinto R. M. A., Salvador J. A. R., Le Roux C., Paixão J. A.
Journal of Organic Chemistry, 2009, 74, 8488-8491. doi: 10.1021/jo9018478.
by Salvador J. A. R., Pinto R. M. A., Silvestre S. M.
Mini Reviews in Organic Chemistry, 2009, 6, 241-274. doi: 10.2174/157019309789371587.
by Pinto, R. M. A., Salvador J. A. R., Le Roux C.
Catalysis Communications, 2008, 9, 465-469. doi: 10.1016/j.catcom.2007.07.022.
by Leitão A. J. L., Salvador J. A. R., Pinto R. M. A., Sá e Melo M. L.
Tetrahedron Letters, 2008, 49, 1694-1697. doi: 10.1016/j.tetlet.2007.12.121.
Catalytic epoxidation and syn-dihydroxylation reactions in steroid chemistry.
by Salvador J. A. R., Silvestre S. M., Moreira V. M.
Current Organic Chemistry, 2008, 12, 492-522. doi: 10.2174/138527208784083897.
CYP17 Inhibitors for Prostate Cancer Treatment. An Update.
by Moreira V. M., Salvador J. A. R., Vasaitis T. S., Njar V. C. O.
Current Medicinal Chemistry, 2008, 15, 868-899. doi: 10.2174/092986708783955428 .
by Pinto R. M. A., Salvador J. A. R., Le Roux C., Carvalho R. A., Silva M. R., Beja A. M., Paixão J. A.
Steroids, 2008, 73, 549-561. doi: 10.1016/j.steroids.2008.01.006.
Allylic and benzylic oxidation reactions with sodium chlorite.
by Silvestre S. M., Salvador J. A. R.
Tetrahedron, 2007, 63, 2439-2445. doi: 10.1016/j.tet.2007.01.012.
Bismuth(III) salts mediated regioselective ring opening of epoxides: an easy route to halohydrins and β-hydroxy nitrates.
by Pinto R. M. A., Salvador J. A. R., Le Roux C.
Tetrahedron, 2007, 63, 9221-9228. doi: 10.1016/j.tet.2007.01.012.
Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors.
by Moreira V. M., Vasaitis T. S., Njar V. C. O., Salvador J. A. R.
Steroids, 2007, 72, 939-948. doi: 10.1016/j.steroids.2007.08.004.
One-pot, high yield synthesis of α-ketols from ∆5-steroids.
by Salvador J. A. R., Moreina V. M., Hanson J. R., Carvalho R.
Steroids, 2006, 71, 266-272. doi: 10.1016/j.steroids.2005.11.002.
by Salvador J. A. R. Silvestre S. M., Moreira V. M.
Current Organic Chemistry, 2006, 10, 2227-2257. doi: 10.2174/138527206778742641.
by Pinto R. M., Salvador J. A. R., Le Roux C.
Synlett, 2006, 13, 2047-2050. doi: 10.1055/s-2006-949608.
by Pinto R. M., Leitão A. J. L., Sá e Melo M. L., Hanson J. R.
Tetrahedron Letters, 2005, 46, 7, 1067-1070. doi: 10.1016/j.tetlet.2004.12.103.
Bismuth-catalysed allylic oxidation using t-butyl hydroperoxide.
by Salvador J. A. R., Silvestre S. M.
Tetrahedron Letters, 2005, 46, 15, 2581-2584. doi: 10.1016/j.tetlet.2005.02.080.
by Silvestre S. M. Salvador J. A. R., Clark J. H.
Journal of Molecular Catalysis A: Chemical, 2004, 219, 143-147. doi: 10.1016/j.molcata.2004.04.034.
by Salvador J. A. R., Clark J. H.
Green Chemistry, 2002, 4, 352-356 doi: 10.1039/B201500P.
by Salvador J. A. R., Clark J. H.
Chemical Communications, 2001, 1, 33-34. doi: 10.1039/B007447K.
Diastereoselective hydroformylation of ∆4-steroids with rhodium-phosphite catalysts.
by Freixa Z., Pereira M. M., Bayon J. C., Silva A. M. S., Salvador J. A. R., Matos Beja A., Paixão J. A., Ramos Silva M.
Tetrahedron Asymmetry, 2001, 12, 1083-1087. doi: 10.1016/S0957-4166(01)00191-4.
by Campos Neves A. S., Sá e Melo M. L., Moreno M. J. S. M., Tavares da Silva E. J., Salvador J. A. R., Pereira da Costa S. C., Martins R. M. L. M.
Tetrahedron, 1999, 55, 3255-3264. doi: 10.1016/S0040-4020(98)01138-7.
Copper-catalysed allylic oxidation of ∆5-steroids by t-butyl hydroperoxide.
by Salvador, J. A. R., Sá e Melo M. L., Campos Neves A. S.
Tetrahedron Letters, 1997, 38, 1, 119-122. doi: 10.1016/S0040-4039(96)02231-9.
by Salvador, J. A. R., Sá e Melo M. L., Campos Neves A. S.
Tetrahedron Letters, 1996, 37, 5, 687-690. doi: 10.1016/0040-4039(95)02243-0.
Ultrasound assisted oxidations and reductions in steroid synthesis.
by Sá e Melo M. L., Moreno M. J. S. M., Pereira da Costa S. C., Salvador J. A. R.,Campos Neves A. S.
Ultrasonics Sonochemistry, 1994, 1, 1, S37-S40. doi: 10.1016/1350-4177(94)90024-8.
Ultrasound assisted zinc reactions in synthesis 1. Efficient reduction of enones.
by Salvador J. A. R., Sá e Melo M. L., Campos Neves A. S.
Tetrahedron Letters, 1993, 34, 2, 357-360. doi: 10.1016/S0040-4039(00)60587-7.
Ultrasound assisted zinc reactions in synthesis 2. A new clemmensen-type reduction.
by Salvador J. A. R., Sá e Melo M. L., Campos Neves A. S.
Tetrahedron Letters, 1993, 34, 2, 361-362. doi: 10.1016/S0040-4039(00)60588-9.
Selected Patents
Triterpenoid derivatives usefull as antiproliferative agents, US Patent. US 8,969,395 B2, 2015.
by Salvador J. A. R., Santos R. C., Serratosa M. C.
by Salvador J. A. R., Santos R. C., Serratosa M. C.
by Salvador J. A. R., Santos R. C., Serratosa M. C.
by Salvador J. A. R., Silvestre S. M.
by Salvador J. A. R., Silvestre S. M.
Copper-catalysed allylic oxidation using alkyl hydroperoxide, US Patent, US 6,252,119 B1, 2001.
by Salvador J. A. R., Sá e Melo M. L., Campos Neves A. S.
by Sandra A.C.Figueiredo, Jorge A.R.Salvador, Roldán Cortés, Marta Cascante
European Journal of Medicinal Chemistry,Vol138, 29 Sep 2017, Pag. 422-437,. DOI: 10.1016/j.ejmech.2017.06.029
by Jorge A.R.Salvador, Ana S.Leal, Ana S.Valdeira, Bruno M.F.Gonçalves, Daniela P.S.Alho, Sandra A.C.Figueiredo, Samuel M.Silvestre,
European Journal of Medicinal Chemistry, In Press 2017. DOI: 10.1016/j.ejmech.2017.07.013
by Ana S. C. Valdeira, Daniel A. Ritt, Deborah K. Morrison, James B. McMahon, Kirk R. Gustafson and Jorge A. R. Salvador
Frontiers in Chemistry, 28 September 2018, DOI: 10.3389/fchem.2018.00434